Invitrogen™ Growth Hormone Receptor Polyclonal Antibody

Catalog No.	Quantity
PIPA579309	100 μg

Catalog No. PIPA579309 Supplier Invitrogen™ Supplier No. PA579309

Description

Rabbit Polyclonal Antibody

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Rat Liver Tissue, Rat Kidney Tissue, Rat Spleen Tissue, Rat Intestine Tissue, Mouse Spleen Tissue, Mouse Testis Tissue, Mouse Liver Tissue, Mouse Kidney Tissue, Mouse Intestine Tissue.

Growth hormone receptor (GHR) is a gene located on chromosome 5p13.1, encoding a transmembrane receptor that plays a critical role in mediating the effects of growth hormone, which is crucial for growth, metabolism, and tissue development. GHR is expressed in various tissues, including the liver, muscle, and adipose tissue, and facilitates the growth hormone signaling pathway by binding to growth hormone, leading to receptor dimerization and activation of intracellular signaling cascades such as the JAK2-STAT5 pathway. This signaling promotes growth and anabolic processes, influencing body composition, insulin sensitivity, and lipid metabolism. Mutations or alterations in the GHR gene can lead to growth disorders like Laron syndrome, characterized by insensitivity to growth hormone. Understanding GHR's structure and function is pivotal for developing therapeutic strategies for growth deficiencies and metabolic syndromes, as modifying GHR signaling pathways can offer potential interventions in related conditions.

Specifications

• Antigen: Growth Hormone Receptor
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 500 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide, 0.05mg thimerosal
• Gene: GHR
• Gene Accession No.: P16310, P16882
• Gene Alias: GH receptor; GH-binding protein; GHBP; GHIP; GHR; GHR/BP; growth hormone binding protein; growth hormone receptor; growth hormone receptor precursor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor precursor splice variant D56; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; Growth hormone-binding protein; MGC124963; MGC156665; serum binding protein; Serum-binding protein; Somatotropin receptor; unnamed protein product
• Gene Symbols: GHR
• Host Species: Rabbit
• Immunogen: A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor (231-247aa DKEHEVRVRSRQRSFEK).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14600, 25235
• Target Species: Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Lyophilized
• Isotype: IgG