Invitrogen™ Growth Hormone Receptor Polyclonal Antibody

Catalog No.	Quantity
PIPA581396	100 μL

Catalog No. PIPA581396 Supplier Invitrogen™ Supplier No. PA581396

Description

Rabbit Polyclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Mouse Growth Hormone Receptor/GHR/GHBP.

Growth hormone receptor (GHR) is a gene located on chromosome 5p13.1, encoding a transmembrane receptor that plays a critical role in mediating the effects of growth hormone, which is crucial for growth, metabolism, and tissue development. GHR is expressed in various tissues, including the liver, muscle, and adipose tissue, and facilitates the growth hormone signaling pathway by binding to growth hormone, leading to receptor dimerization and activation of intracellular signaling cascades such as the JAK2-STAT5 pathway. This signaling promotes growth and anabolic processes, influencing body composition, insulin sensitivity, and lipid metabolism. Mutations or alterations in the GHR gene can lead to growth disorders like Laron syndrome, characterized by insensitivity to growth hormone. Understanding GHR's structure and function is pivotal for developing therapeutic strategies for growth deficiencies and metabolic syndromes, as modifying GHR signaling pathways can offer potential interventions in related conditions.

Specifications

• Antigen: Growth Hormone Receptor
• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene: GHR
• Gene Accession No.: P16882
• Gene Alias: GH receptor; GH-binding protein; GHBP; GHIP; GHR; GHR/BP; growth hormone binding protein; growth hormone receptor; growth hormone receptor precursor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor precursor splice variant D56; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; Growth hormone-binding protein; MGC124963; MGC156665; serum binding protein; Serum-binding protein; Somatotropin receptor; unnamed protein product
• Gene Symbols: GHR
• Host Species: Rabbit
• Immunogen: Recombinant Mouse Growth Hormone Receptor/GHR/GHBP protein (Met1-Gln273).
• Purification Method: Antigen affinity chromatography, Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 14600
• Target Species: Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG