GRP94 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS0194R

Catalog No. 50-198-0131

Description

GRP94 is a 803 amino acid protein belonging to the heat shock protein 90 family. It acts as a molecular chaperone that functions in the processing and transport of secreted proteins. GRP94 and its N-terminal fragment stimulates CTL expansion and maturation of human monocyte-derived dendritic cells (MDDC). It plays a central role in innate as well as acquired immunity, maturation and chemotaxis of dendritic cells, Ab production, cross-priming, as a potential marker in breast cancer and is a peptide acceptor in endoplasmic reticulum and an accessory to peptide loading of MHC class I molecules. Expression of GRP94 suppressed A23187-induced apoptosis and stabilized calcium homeostasis. GRP94 is expressed in melanoma or liver metastases of colon carcinoma cells, human gastric carcinoma BGC-823 cells.

Specifications

• Antigen: GRP94
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HSP90B1
• Gene Alias: 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250; 98 kDa protein kinase; BOS_5572; ECGP; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250; endoplasmin-like protein; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; ERp99; glucose-regulated protein; glucose-regulated protein GRP94; Gp96; gp96 homolog; GRP94; GRP-94; Heat shock 108 kDa protein; heat shock protein 108; heat shock protein 90 beta family member 1; Heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein 90kDa beta family member 1 L homeolog; heat shock protein 90kDa beta, member 1; heat shock protein gp96; HEL35; HEL-S-125m; HSP 108; hsp108; HSP90 beta; Hsp90b1; hsp90b1 {ECO:0000250; hsp90b1.L; LOC100009456; Polymorphic tumor rejection antigen 1; PPK 98; ppk98; stress-inducible tumor rejection antigen gp96; TA-3; Targ2; TRA1; Tra-1; Transferrin-binding protein; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; Tumor rejection antigen 1; Tumor rejection antigen gp96; UniProtKB:P08113}; XELAEV_18017384mg
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 7184
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: P14625
• Gene Symbols: HSP90B1
• Immunogen: KLH conjugated synthetic peptide derived from human GRP94.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG