Invitrogen™ GRPR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5102667

Catalog No. PIPA5102667

Description

Antibody detects endogenous levels of total GRPR.

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

Specifications

• Antigen: GRPR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GRPR
• Gene Alias: BB2; BB2R; bombesin receptor 2; gastrin releasing peptide receptor; gastrin-releasing peptide receptor; GRP receptor; GRP-preferring bombesin receptor; GRPR; GRP-R
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14829, 24938, 2925
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P21729, P30550, P52500
• Gene Symbols: GRPR
• Immunogen: A synthesized peptide derived from human GRPR(Accession P30550), corresponding to amino acid residues V177-S227.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov