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Invitrogen™ GRPR Polyclonal Antibody
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Catalog No. OPA115619
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25 μg
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Catalog No. Quantity
OPA115619 25 μg
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Catalog No. OPA115619 Supplier Invitrogen™ Supplier No. OPA115619
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: Human pancreas, islets of Langerhans. By immunohistochemistry, OPA1-15619 detects GRPR in formalin fixed, paraffin embedded human tissues.

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GRPR
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% sodium azide
Gene GRPR
Gene Accession No. P30550
Gene Alias BB2; BB2R; bombesin receptor 2; gastrin releasing peptide receptor; gastrin-releasing peptide receptor; GRP receptor; GRP-preferring bombesin receptor; GRPR; GRP-R
Gene Symbols GRPR
Host Species Rabbit
Immunogen Synthetic 18 amino acid peptide from 2nd extracellular domain of human GRPR.
Purification Method Antigen affinity chromatography
Quantity 25 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100056400, 100344857, 100517439, 2925, 491754
Target Species Bat, Canine, Horse, Human, Monkey, Pig, Rabbit
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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