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  5. Tocris Bioscience™ GS 143

Tocris Bioscience™ GS 143
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Catalog No. 563650
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

β-TrCP1 ligase inhibitor

GS 143 is a β-TrCP1 ligase inhibitor. Inhibits IκBα ubiquitination (IC50 = 5.2 μM) without affecting proteasome activity. Blocks LPS-induced expression of inflammatory cytokines in human myelomonocytic cells. Suppresses antigen-induced NFκB expression, inflammation and mucus production in airways of OVA-sensitized mice.

Specifications

Chemical Name or Material 4-[4-[[5-(2-Fluorophenyl)-2-furanyl]methylene]-4,5-dihydro-5-oxo-3-(phenylmethyl)-1H-pyrazol-1-yl]benzoic acid
CAS 916232-21-8
Quantity 50 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C28H19FN2O4
Formula Weight 466.46
Purity >98%
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