Invitrogen™ GSC2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA560198

Catalog No. PIPA560198

Description

Immunogen sequence: PFSIEHILSS LPERSLPARA ACPPQPAGRQ SPAKPEEP Highest antigen sequence identity to the following orthologs: Mouse - 63%, Rat - 68%.

Goosecoidlike (GSCL) resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology.Goosecoidlike (GSCL), a homeodomain-containing gene, resides in the critical region for VCFS/DGS on 22q11. Velocardiofacial syndrome (VCFS) is a developmental disorder characterized by conotruncal heart defects, craniofacial anomalies, and learning disabilities. VCFS is phenotypically related to DiGeorge syndrome (DGS) and both syndromes are associated with hemizygous 22q11 deletions. Because many of the tissues and structures affected in VCFS/DGS derive from the pharyngeal arches of the developing embryo, it is believed that haploinsufficiency of a gene involved in embryonic development may be responsible for its etiology. The gene is expressed in a limited number of adult tissues, as well as in early human development.

Specifications

• Antigen: GSC2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GSC2
• Gene Alias: 4930568H22Rik; goosecoid homebox 2; goosecoid homeobox 2; GSC2; GSC-2; GSCL; GSC-L; homeobox protein goosecoid-2; Homeobox protein goosecoid-like; LOW QUALITY PROTEIN: homeobox protein goosecoid-2
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2928
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O15499
• Gene Symbols: GSC2
• Immunogen: Recombinant protein corresponding to Human GSC2. Recombinant protein control fragment (Product #RP-99858).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov