Invitrogen™ GSDMD Monoclonal Antibody (A8D7)

Catalog No.	Quantity
FEMA550595	100 μL

Catalog No. FEMA550595 Supplier Invitrogen™ Supplier No. MA550595

Description

Mouse Monoclonal Antibody

Positive control: PC-3 cell lysate, NIH/3T3 cell lysate, THP-1 cell lysate. Predicted band size: 53 kDa Subcellular Location: Cytosol, Inflammasome; Secreted, Cell membrane.

GSDMD (gasdermin-D) promotes pyroptosis in response to microbial infection and danger signals. It is produced by the cleavage of gasdermin-D by inflammatory caspases CASP1 or CASP4 in response to canonical, as well as, non-canonical (such as cytosolic LPS) inflammasome activators. After cleavage, GSDMD moves to the plasma membrane where it strongly binds to inner leaflet lipids including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-biphosphate, phosphatidylinositol (3,4,5)-biphosphate, phosphatidic acid, and phosphatidylserine. GSDMD also exhibits bactericidal activity.

Specifications

• Antigen: GSDMD
• Applications: Western Blot
• Classification: Monoclonal
• Clone: A8D7
• Concentration: 2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.1% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
• Gene: GSDMD
• Gene Accession No.: P57764, Q9D8T2
• Gene Alias: 1810036L03Rik; AW558049; DF5L; Dfna5l; FKSG10; gasdermin D; gasdermin domain containing 1; gasdermin domain-containing protein 1; Gasdermin-D; Gasdermin-D, C-terminal; Gasdermin-D, N-terminal; GSDMD; GSDMDC1; GSDMD-CT; GSDMD-NT; M2-4
• Gene Symbols: GSDMD
• Host Species: Mouse
• Immunogen: Recombinant protein within human GSDMD aa 101-300/484.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 69146, 79792
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG2b