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  5. Tocris Bioscience™ GSK 1016790A

Tocris Bioscience™ GSK 1016790A
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Catalog No. 643310
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Catalog No. Quantity
64-331-0 10 mg
64-335-0 50 mg
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Catalog No. 64-331-0 Supplier Tocris Bioscience™ Supplier No. 6433/10
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Description

Potent TRPV4 agonist

GSK 1016790A is a potent TRPV4 agonist; elicits Ca2+ influx in human and mouse TRPV4-expressing HEK cells (EC50 values of 2.1 and 18 nM, respectively). Enhances insulin mRNA expression. Increases ERK1/2 phosphorylation and NO production. Exhibits no activity at TRPM8 and TRPA1 (20 μM) channels. Induces bladder overactivity in TRPV4+/+ mice.

Specifications

Quantity 10 mg
Molecular Formula C28H32Cl2N4O6S2
Formula Weight 655.61
Product Type Agonist
Purity 98%
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