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  5. Tocris Bioscience™ GSK 1562590 hydrochloride

Tocris Bioscience™ GSK 1562590 hydrochloride
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Catalog No. 511050 Shop All R&D Systems Products
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51-105-0 50 mg
51-101-0 10 mg
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Catalog No. 51-105-0 Supplier Tocris Bioscience™ Supplier No. 5110/50
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Description

High affinity, selective urotensin II (UT) receptor antagonist

GSK 1562590 hydrochloride is a high affinity and selective urotensin II (UT) receptor antagonist (pKi values are 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors respectively). Exhibits selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. Supresses human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo. Inhibits the hU-II-induced increase in mean blood pressure in vivo. Orally active.

Specifications

Quantity 50 mg
Product Type GSK 1562590 hydrochloride
Purity >98%
Molecular Weight (g/mol) 617.95
Inhibitors GSK 1562590 hydrochloride

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