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  5. Tocris Bioscience™ GSK 1838705

Tocris Bioscience™ GSK 1838705
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Catalog No. 511150
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Catalog No. Quantity
51-115-0 50 mg
51-111-0 10 mg
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Catalog No. 51-115-0 Supplier Tocris Bioscience™ Supplier No. 5111/50
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Description

Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)

GSK 1838705 is a potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor (IC50 values are 1.6 and 2 nM, respectively). Also inhibits anaplastic lymphoma kinase (ALK) (IC50 = 0.5 nM). Displays > 800-fold selectivity for IR, IGFR1 and ALK over a panel of 44 kinases including JNK. Blocks proliferation of cancer cell lines in vitro, and causes complete regression of ALK-dependent tumors in vivo. Orally bioavailable.

Specifications

Quantity 50 mg
Product Type GSK 1838705
Purity >98%
Molecular Weight (g/mol) 532.57
Inhibitors GSK 1838705

For Research Use Only

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