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Tocris Bioscience™ GSK 2830371
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Catalog No. 514010 Shop All R&D Systems Products
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Catalog No. Quantity
51-401-0 10 mg
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Catalog No. 51-401-0 Supplier Tocris Bioscience™ Supplier No. 5140/10
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Description

Potent and selective allosteric inhibitor of Wip1 phosphatase

GSK 2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo. Potentiates growth inhibitory effects of MDM2 inhibition in cancer cell lines in a p53-dependent manner. Orally bioavailable.

Specifications

Quantity 10 mg
Product Type GSK 2830371
Purity >98%
Molecular Weight (g/mol) 461.02
Inhibitors GSK 2830371

For Research Use Only

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