Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 649710

Tocris Bioscience™ GSK 2833503A
GREENER_CHOICE

Catalog No. 649710
Change view
Click to view available options
Quantity:
10 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
64-971-0 10 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Catalog No. 64-971-0 Supplier Tocris Bioscience™ Supplier No. 6497/10
Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Potent and selective TRPC6 and TRPC3 antagonist

GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cells in vitro and in cardiomyocytes.

Specifications

Chemical Name or Material [2-[(4-Chloro-2-fluorophenyl)amino]-5-methyl-4-thiazolyl][(2 S,3 S)-2,3-dimethyl-1-piperidinyl]methanone
CAS 1366234-01-6
Quantity 10 mg
Target TRPC Channel Blockers
Molecular Formula C18H21ClFN3OS
Purity 0.98
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.