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Tocris Bioscience™ GSK 2833503A
GREENER_CHOICE

Catalog No. 649710
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Quantity:
10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective TRPC6 and TRPC3 antagonist

GSK 2833503A is a potent and selective TRPC6 and TRPC3 antagonist (IC50 = 3-16 nM and 21-100 nM, respectively). GSK 2833503A exhibits >63-fold selectivity over other ion channels, including other TRP channels, CaV1.2, hERG and NaV1.5. GSK 2833503A suppresses angiotensin II or endothelin-1-induced cardiac hypertrophy signaling in HEK293 cells in vitro and in cardiomyocytes.

Specifications

Chemical Name or Material [2-[(4-Chloro-2-fluorophenyl)amino]-5-methyl-4-thiazolyl][(2 S,3 S)-2,3-dimethyl-1-piperidinyl]methanone
CAS 1366234-01-6
Quantity 10 mg
Target TRPC Channel Blockers
Molecular Formula C18H21ClFN3OS
Purity 0.98
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