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Tocris Bioscience™ GSK 2837808A
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Catalog No. 518910
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Catalog No.
51-891-0 10mg
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Description

Potent and selective LDHA inhibitor

GSK 2837808A is a potent and selective lactate dehydrogenase A and B (LDHA and LDHB) inhibitor (IC50 values are 2.6 and 43 nM for LDHA and LDHB respectively). Inhibits lactate production in selected cancer cell lines. Reduces glucose uptake and enhances mitochondrial oxygen consumption in Snu398 hepatocellular carcinoma cells. Inhibits proliferation and induces apoptosis in Snu398 cells. Inhibits transcription of histone 2B (H2B) gene in HCT116 and NCM460 cells. Cell permeable.

Specifications

CAS 1445879-21-9
Quantity 10 mg
Molecular Formula 3-[[3-[(Cyclopropylamino)sulfonyl]-7-(2,4-dimethoxy-5-pyrimidinyl)-4-quinolinyl]amino]-5-(3,5-difluorophenoxy)benzoic acid
Product Type GSK 2837808A
Purity 98%
Molecular Weight (g/mol) M.W. (Observed): 649.62
Inhibitors GSK 2837808A

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