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Tocris Bioscience™ GSK 343
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Catalog No. 612850
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Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent and selective SAM-competitive EZH2 inhibitor

GSK 343 is a potent and selective SAM-competitive EZH2 inhibitor (IC50 = 4 nM), that exhibits >60 fold selectivity for EZH2 over EZH1 and a range of other methyltransferases. GSK 343 decreases H3K27me3 levels in breast cancer cells and inhibits proliferation of prostate cancer cell lines in vitro.

Specifications

Chemical Name or Material N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide
CAS 1346704-33-3
Assay Percent Range >98%
Quantity 50 mg
Molecular Formula C31H39N7O2
Formula Weight Observed MW: 541.69
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