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R&D Systems™ GSK 343
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Catalog No. 612810 Shop All Novus Biologicals Products
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61-281-0 10 mg
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Catalog No. 61-281-0 Supplier R&D Systems™ Supplier No. 6128/10

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Description

A Tocris product, part of R&D Systems. Potent and selective SAM-competitive EZH2 inhibitor

GSK 343 is a potent and selective SAM-competitive EZH2 inhibitor (IC50 = 4 nM), that exhibits >60 fold selectivity for EZH2 over EZH1 and a range of other methyltransferases. GSK 343 decreases H3K27me3 levels in breast cancer cells and inhibits proliferation of prostate cancer cell lines in vitro.

Specifications

Chemical Name or Material N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[2-(4-methyl-1-piperazinyl)-4-pyridinyl]-1H-indazole-4-carboxamide
CAS 1346704-33-3
Assay Percent Range >98%
Quantity 10 mg
Product Line Tocris
Molecular Formula C31H39N7O2
Formula Weight Observed MW: 541.69
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