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  5. Tocris Bioscience™ GSK 583

Tocris Bioscience™ GSK 583
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Catalog No. 64805
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25 mg
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64-805 5 mg
64-802-5 25 mg
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Catalog No. 64-805 Supplier Tocris Bioscience™ Supplier No. 6480/5
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Description

Potent RIP2 kinase inhibitor; orally bioavailable and cell permeable

GSK 583 is a potent RIPK2 inhibitor (IC50 values are 2 and 5 nM at rat and human kinases, respectively). Displays selectivity for RIP2K over p38α, VEGFR2 and a panel of 300 kinases. Exhibits some inhibition at BRK and Aurora A. Also displays similar binding affinity, but no detectable functional activity at RIP3. Active in vivo. Moderately orally bioavailable and cell permeable.

Specifications

Chemical Name or Material 6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine
CAS 1346547-00-9
Quantity 5 mg
Molecular Formula C20H19FN4O2S
Purity 98%
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