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  5. Tocris Bioscience™ GSK'872

Tocris Bioscience™ GSK'872
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Catalog No. 649210
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Catalog No. Quantity
64-921-0 10 mg
64-925-0 50 mg
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Description

Potent and selective RIP3 kinase inhibitor

GSK'872 is a potent and selective receptor activating protein kinase 3 (RIP3) inhibitor (IC50 = 1.3 nM). Exhibits >1000-fold selectivity for RIP3 over a panel of 300 other kinases including RIP1. Inhibits TNF-induced cell death in 3T3-SA cells and TLR3-induced necrosis in fibroblasts in vitro. Blocks necroptosis of primary human neutrophils from whole blood. Also induces apoptosis at higher concentrations (3 - 10 μM).

Specifications

Chemical Name or Material N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine
CAS 1346546-69-7
Quantity 10 mg
Molecular Formula C19H17N3O2S2
Formula Weight 383.49
Purity 98%
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