Invitrogen™ GSPT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA599621

Catalog No. PIPA599621

Description

Antibody detects endogenous levels of total eRF3/GSPT1.

eRF3a (eukaryotic peptide chain release factor subunit 3a), also known as GSPT1 (G1 to S phase transition 1), is a 499 amino acid protein that belongs to the GTP-binding elongation factor family and is involved in the regulation of cell growth, specifically via control of translation termination. Human eRF3a shares 94% sequence identity with its mouse counterpart, suggesting a conserved function between species. The gene encoding eRF3a maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth.

Specifications

• Antigen: GSPT1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GSPT1
• Gene Alias: 551G9.2; AI314175; AI326449; AV307676; C79774; ELF; ERF3A; ETF3A; Eukaryotic peptide chain release factor GTP-binding subunit ERF3A; eukaryotic peptide chain release factor subunit 3a; eukaryotic polypeptide chain release factor 3; G1 to phase transition 1; G1 to S phase transition 1; G1 to S phase transition protein 1; G1 to S phase transition protein 1 homolog; G1st; G1-to-S phase transition 1; G1-to-S transition GTP binding protein; GSPT1; GST1; Gst-1; guanine nucleotide regulatory protein
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14852, 2935
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P15170, Q8R050
• Gene Symbols: GSPT1
• Immunogen: A synthesized peptide derived from human GSPT1(Accession P15170), corresponding to amino acid residues N268-L318.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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