Invitrogen™ GSTA2 Polyclonal Antibody

Catalog No.	Quantity
PIPA521670	100 μL

Catalog No. PIPA521670 Supplier Invitrogen™ Supplier No. PA521670

Description

Rabbit Polyclonal Antibody

Recommended positive controls: HepG2. Predicted reactivity: Pig (82%), Rhesus Monkey (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation.

Specifications

• Antigen: GSTA2
• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene: Gsta2
• Gene Accession No.: P04903, P09210
• Gene Alias: 13-hydroperoxyoctadecadienoate peroxidase; Androst-5-ene-3,17-dione isomerase; glutathione S-alkyltransferase A2; glutathione S-aralkyltransferase A2; glutathione S-aryltransferase A2; glutathione S-transferase A2; glutathione S-transferase alpha 2; glutathione S-transferase alpha-1; Glutathione S-transferase GT41A; glutathione S-transferase Ya subunit; glutathione S-transferase Ya-1; glutathione S-transferase, alpha 2 (Yc2); Glutathione-S-transferase alpha type (Yc2); glutathione-S-transferase, alpha type2; GST 1-1; GST 1a-1a; GST A1-1; GST B; GST class-alpha member 2; GST HA subunit 2; GST Ya1; GST2; Gst2-2; Gsta1; Gsta2; GSTA2-2; Gstc2; Gstc-2; GST-gamma; GTA2; GTH2; Ligandin; liver GST2; S-(hydroxyalkyl)glutathione lyase A2; testis tissue sperm-binding protein Li 59n
• Gene Symbols: Gsta2
• Host Species: Rabbit
• Immunogen: Recombinant protein encompassing a sequence within the center region of human GSTA2. The exact sequence is proprietary.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 24422, 2939
• Target Species: Human, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG