Invitrogen™ GSTA3 Polyclonal Antibody

Catalog No.	Quantity
PIPA543184	100 μL

Catalog No. PIPA543184 Supplier Invitrogen™ Supplier No. PA543184

Description

Rabbit Polyclonal Antibody

Peptide sequence: SSLISNFPLL KALKTRISNL PTVKKFLQPG SPRKPPADAK ALEEARKIFR Sequence homology: Human: 100%; Mouse: 79%; Sheep: 77%.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class genes that are located in a cluster mapped to chromosome 6. Genes of the alpha class are highly related and encode enzymes with glutathione peroxidase activity. However, during evolution, this alpha class gene diverged accumulating mutations in the active site that resulted in differences in substrate specificity and catalytic activity. The enzyme encoded by this gene catalyzes the double bond isomerization of precursors for progesterone and testosterone during the biosynthesis of steroid hormones. An additional transcript variant has been identified, but its full length sequence has not been determined.

Specifications

• Antigen: GSTA3
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene: Gsta3
• Gene Accession No.: Q16772
• Gene Alias: glutathione S-alkyltransferase A3; glutathione S-aralkyltransferase A3; glutathione S-aryltransferase A3; glutathione S-transferase A3; glutathione S-transferase A3 subunit; glutathione S-transferase A3-3; glutathione S-transferase A5; glutathione S-transferase alpha 1; glutathione S-transferase alpha 3; glutathione S-transferase alpha-3; Glutathione S-transferase alpha-5; glutathione S-transferase Ya3; Glutathione S-transferase Yc; glutathione S-transferase Yc-1; glutathione S-transferase Yc1 subunit; Glutathione S-transferase Yc-2; glutathione S-transferase Yc2 subunit; glutathione S-transferase, alpha 3; Glutathione-S-transferase alpha type (Ya); GST 2-2; GST A3-3; GST A5-5; GST AA; GST class-alpha member 3; GST Yc1; GST Yc2; Gst2-3; Gsta1; GSTA3; GSTA3-3; Gsta5; Gstyc; Gstyc1; Gstyc2; GTA3; MGC22232; S-(hydroxyalkyl)glutathione lyase A3; Yc1; Yc2
• Gene Symbols: Gsta3
• Host Species: Rabbit
• Immunogen: Synthetic peptide directed towards the middle region of human GSTA3.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2940
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov