Invitrogen™ GSTM5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5116635

Catalog No. PIPA5116635

Description

Positive Samples: Mouse heart, Mouse kidney, Mouse liver, Rat testis, Rat brain Immunogen sequence: LENQVMDNHM ELVRLCYDPD FEKLKPKYLE ELPEKLKLYS EFLGKRPWFA GDKITFVDFL AYDVLDMKRI FEPKCLDAFL NLKDFISRFE GLKKISAYMK SSQFLRGLLF GKSATWNSK.

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds.

Specifications

• Antigen: GSTM5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GSTM5
• Gene Alias: fibrous sheath component 2; Fsc2; glutathione S-alkyltransferase M5; glutathione S-aralkyltransferase M5; glutathione S-aryltransferase M5; glutathione S-transferase M5; glutathione S-transferase Mu 5; glutathione S-transferase, mu 5; glutathione-S-transferase, mu 5; GST class-mu 5; Gstm3; GSTM5; GSTM5-5; GTM5; S-(hydroxyalkyl)glutathione lyase M5
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14866, 64352
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.2 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: P48774, Q9Z1B2
• Gene Symbols: GSTM5
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100 to the C-terminus of human GSTM5 (NP_0008422).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG