Invitrogen™ GTF2A2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103306

Catalog No. PIPA5103306

Description

Antibody detects endogenous levels of total TF2A2.

Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995).

Specifications

• Antigen: GTF2A2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gtf2a2
• Gene Alias: general transcription factor II A, 2; general transcription factor IIA 2; general transcription factor IIA subunit 2; general transcription factor IIA, 2; general transcription factor IIA, 2 (12kD subunit); general transcription factor IIA, 2, 12kDa; Gtf2a2; HsT18745; T18745; TF2A2; TFIIA; TFIIA gamma subunit; TFIIA p12 subunit; TFIIA-12; Tfiia2; TFIIA-gamma; TFIIAS; TfIIg; Transcription initiation factor IIA gamma chain; transcription initiation factor IIA subunit 2
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 235459, 2958, 83828
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: O08950, P52657, Q80ZM7
• Gene Symbols: Gtf2a2
• Immunogen: A synthesized peptide derived from human GTF2A2(Accession P52657), corresponding to amino acid residues Q27-N77.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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