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Invitrogen™ GTF2B Polyclonal Antibody
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Catalog No. PIPA584509
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PIPA584509 100 μL
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Catalog No. PIPA584509 Supplier Invitrogen™ Supplier No. PA584509
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LPRDTCPNHP DAILVEDYRA GDMICPECGL VVGDRVIDVG SEWRTFSNDK ATKDPSRVGD SQNPLLSDGD LSTMIGKGTG AASFDEFG Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 85%.

Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GTF2B
Applications ChIP Assay, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GTF2B
Gene Accession No. Q00403
Gene Alias general transcription factor 2B L homeolog; general transcription factor IIB; general transcription factor TFIIB; GTF2B; gtf2b.L; gtf2b-a; gtf2b-b; LOW QUALITY PROTEIN: transcription initiation factor IIB; MGC137096 protein; RNA polymerase II alpha initiation factor; RNA polymerase II transcription factor IIB; RP11-82K18.1; S300-II; TF2B; tfiib; Transcription initiation factor IIB; Transcription initiation factor IIB-like protein; wu:fc44c11; XELAEV_18023356mg; XLTFIIB; zgc:66258
Gene Symbols GTF2B
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human GTF2B. Recombinant protein control fragment (Product #RP-101317).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2959
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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