Invitrogen™ GTF2E1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA546858

Catalog No. PIPA546858

Description

Peptide sequence: VADDPIVMVA GRPFSYSEVS QRPELVAQMT PEEKEAYIAM GQRMFEDLFE Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%.

The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits of relative molecular mass 57, 000 (TFIIE-alpha) and 34, 000 (TFIIE-beta) and joins the preinitiation complex after RNA polymerase II and TFIIF. TFIIE-alpha is necessary for transcription initiation together with TFIIE-beta, and recombinant TFIIE-alpha can fully replace the natural subunit in an in vitro transcription assay. Its sequence contains several interesting structural motifs (leucine repeat, zinc finger and helix-turn-helix) and sequence similarities to bacterial sigma factors that suggest direct involvement in the regulation of transcription initiation.

Specifications

• Antigen: GTF2E1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GTF2E1
• Gene Alias: 2610024P03Rik; 56kDa; AI303800; FE; general transcription factor II E, polypeptide 1 (alpha subunit); general transcription factor II E, polypeptide 1 (alpha subunit, 56kDa); general transcription factor IIE 56 kDa subunit; General transcription factor IIE subunit 1; General transcription factor IIE subunit 1-like protein; general transcription factor IIE, polypeptide 1 (alpha subunit); general transcription factor IIE, polypeptide 1 (alpha subunit, 56kDa); general transcription factor IIE, polypeptide 1, alpha; general transcription factor IIE, polypeptide 1, alpha 56kDa; GTF2E1; TF2E1; TFIIE alpha subunit; TFIIE-A; TFIIE-alpha; Transcription initiation factor IIE subunit alpha
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2960
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: P29083
• Gene Symbols: GTF2E1
• Immunogen: Synthetic peptide directed towards the C-terminal of human GTF2E1 (aa 390-439).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov