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Invitrogen™ GTF2E1 Polyclonal Antibody
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Catalog No. PIPA590339
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100 μL
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PIPA590339 100 μL
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Catalog No. PIPA590339 Supplier Invitrogen™ Supplier No. PA590339
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LAGGHHREAW ATKGPSYEDL YTQNVVINMD DQEDLHRASL EGKSAKERPI WLRESTVQGA YGSEDMKEGG IDMDAFQERE EGHAGPDDNE EVMRALLIHE KKTSSAMAGS VGAAAPVTAA NGSDSESETS ESDDDSPPRP AAVAVHKREE DEEEDDEFEE VADDPIVMVA GRPFSYSEVS QRPELVAQMT PEEKEAYIAM GQRMFEDLFE; Positive Samples: HeLa, Jurkat, A-431, Mouse brain, Mouse spleen, Mouse testis; Cellular Location: Nucleus.

The general transcription factor TFIIE has an essential role in eukaryotic transcription initiation together with RNA polymerase II and other general factors. Human TFIIE consists of two subunits of relative molecular mass 57, 000 (TFIIE-alpha) and 34, 000 (TFIIE-beta) and joins the preinitiation complex after RNA polymerase II and TFIIF. TFIIE-alpha is necessary for transcription initiation together with TFIIE-beta, and recombinant TFIIE-alpha can fully replace the natural subunit in an in vitro transcription assay. Its sequence contains several interesting structural motifs (leucine repeat, zinc finger and helix-turn-helix) and sequence similarities to bacterial sigma factors that suggest direct involvement in the regulation of transcription initiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GTF2E1
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 2.82 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene GTF2E1
Gene Accession No. P29083, Q9D0D5
Gene Alias 2610024P03Rik; 56kDa; AI303800; FE; general transcription factor II E, polypeptide 1 (alpha subunit); general transcription factor II E, polypeptide 1 (alpha subunit, 56kDa); general transcription factor IIE 56 kDa subunit; General transcription factor IIE subunit 1; General transcription factor IIE subunit 1-like protein; general transcription factor IIE, polypeptide 1 (alpha subunit); general transcription factor IIE, polypeptide 1 (alpha subunit, 56kDa); general transcription factor IIE, polypeptide 1, alpha; general transcription factor IIE, polypeptide 1, alpha 56kDa; GTF2E1; TF2E1; TFIIE alpha subunit; TFIIE-A; TFIIE-alpha; Transcription initiation factor IIE subunit alpha
Gene Symbols GTF2E1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 230-439 of human GTF2E1 (NP_0055042).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2960, 303918, 74197
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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