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Invitrogen™ Gtf2h5 Polyclonal Antibody
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Catalog No. PIPA570178
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100 μL
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PIPA570178 100 μL
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Catalog No. PIPA570178 Supplier Invitrogen™ Supplier No. PA570178
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 79%.

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. Necessary for the stability of the TFIIH complex and for the presence of normal levels of TFIIH in the cell.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Gtf2h5
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene GTF2H5
Gene Accession No. Q8K2X8
Gene Alias 2700017P07Rik; 2810432H05Rik; bA120J8.2; C6orf175; D17Wsu155e; General transcription factor IIH polypeptide 5; General transcription factor IIH subunit 5; general transcription factor IIH, polypeptide 5; GTF2H5; RGD1560991; si:dkey-12h9.4; TFB5; TFB5 ortholog; TFIIH; TFIIH basal transcription factor complex TTDA subunit; TFIIH basal transcription factor complex TTD-A subunit; TGF2H5; TTD; TTD3; TTDA; TTD-A; Unknown (protein for MGC:134263); Unknown (protein for MGC:153434); zgc:153434
Gene Symbols GTF2H5
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human Gtf2h5 (aa 18-67).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 66467
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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