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Invitrogen™ GTF3C3 Polyclonal Antibody
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Catalog No. PIPA5111643
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100 μL
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PIPA5111643 100 μL
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Catalog No. PIPA5111643 Supplier Invitrogen™ Supplier No. PA5111643
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RETKKMMKEK RPRSKLPRAL RGLMGEANIR FARGEREEAI LMCMEIIRQA PLAYEPFSTL AMIYEDQGDM EKSLQFELIA AHLNPSDTEE WVRLAEMSLE QDNIKQAIFC YTKALKYEPT NVRYLWERSS LYEQMGD Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 99%.

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in malignant cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of malignant cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GTF3C3
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene GTF3C3
Gene Accession No. Q9Y5Q9
Gene Alias AL022818; general transcription factor 3C polypeptide 3; general transcription factor IIIC subunit 3; general transcription factor IIIC, polypeptide 3; general transcription factor IIIC, polypeptide 3, 102kDa; GTF3C3; im:7136784; LOC553318 protein; TF3C3; TF3C-gamma; TFIIIC 102 kDa subunit; TFIIIC102; TFiiiC2-102; TFIIICgamma; Transcription factor IIIC 102 kDa subunit; Transcription factor IIIC subunit gamma; transcription factor IIIC-gamma subunit
Gene Symbols GTF3C3
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human GTF3C3. Recombinant protein control fragment (Product #RP-107680).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9330
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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