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GTF3C3/TFIIIC102 Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No. 501559854
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50-155-9854 10 μL
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Catalog No. 50-155-9854 Supplier Bethyl Laboratories, Inc Supplier No. A301237AT
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Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt.

RNA polymerase (pol) III synthesizes tRNA, 5s rRNA, 7SL RNA and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo, since cells must duplicate its protein components before division. Therefore, in order to maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, which requires the presence of the TFIIIB and TFIIIC2 transcription factor complexes. The TFIIIC2 complex is composed of five subunits, TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90 and TFIIIC63, that are overexpressed in adenovirus transformed cells as well as in maligt cells in vivo, such as ovarian carcinomas. TFIIIC2 recruits RNA pol III and TFIIIB to promoter elements and may be a key component in the deregulation of maligt cells. The TFIIIB complex includes the TATA-binding protein (TBP), TFIIB-related factor 1 (BRF1) and TFIIIB, the expression of which are also upregulated in transformed cells. In many carcinomas, the tumor suppressors retinoblastoma (RB) and p53 are inactivated, which affects their ability to bind and inactivate the function of TFIIIB.

Specifications

Antigen GTF3C3/TFIIIC102
Applications Immunoprecipitation
Classification Polyclonal
Concentration 1 mg/ml
Conjugate Unconjugated
Formulation phosphate, tris citrate with 0.09% sodium azide; pH 7-8
Gene GTF3C3
Gene Accession No. Q9Y5Q9
Gene Alias General transcription factor 3C polypeptide 3, Transcription factor IIIC 102 kDa subunit, TFIIIC 102 kDa subunit, TFIIIC102, Transcription factor IIIC subunit gamma, TF3C-gamma, GTF3C3
Gene Symbols GTF3C3
Host Species Rabbit
Immunogen Between 100 and 150
Purification Method Antigen affinity chromatography
Quantity 10 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9330
Target Species Human
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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