Invitrogen™ GTPBP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA556738

Catalog No. PIPA556738

Description

Immunogen sequence: DGNIEYKLKL VNPSQYRFEH LVTQMKWRLQ EGRGEAVYQI GVEDNGLLVG LAEEEMRASL KTLHRMAEKV GADITVLRER EVDYDSDMPR KITEVLVRKV P Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 100%.

Small G proteins act as molecular switches for regulation of variety of cellular processes, such as nuclear transport, signal transduction, membrane trafficking and protein synthesis. GTPBP2 (GTP-binding protein 2) is a 602 amino acid G protein that is expressed in kidney, skeletal muscle, testis, brain and thymus, though it is not detected in liver. Expression of GTPBP2 is enhanced by ©-interferon stimulation in HeLa cells, THP-1 cells and thioglycollate-elicited mouse peritoneal macrophages. There are four isoforms of GTPBP2 that are expressed as a result of alternative splicing events. Since mutation of the gene encoding GTPBP1 does not lead to any phenotypic abnormalities, it is thought that there may be a genetic redundancy to make up for GTPBP1 lack-of-function. GTPBP2 shares 44% sequence similarity with GTPBP1 and also overlaps in expression pattern, suggesting that the GTPBP2 gene may compensate for GTPBP1 genetic abnormalities.

Specifications

• Antigen: GTPBP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gtpbp2
• Gene Alias: GTP binding protein 2; GTP-binding protein 2; GTP-binding-like protein 2; gtpbp2; I79_024595; nmf205
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54676
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9BX10
• Gene Symbols: Gtpbp2
• Immunogen: Recombinant protein corresponding to Human GTPBP2. Recombinant protein control fragment (Product #RP-94951).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG