Invitrogen™ GUCY1A3 Monoclonal Antibody (3G6B2)

Catalog No.	Quantity
PIMA517086	100 μg

Catalog No. PIMA517086 Supplier Invitrogen™ Supplier No. MA517086

Description

Mouse Monoclonal Antibody

MA5-17086 targets GUCY1A3 in indirect ELISA, FACS, ICC, IHC, IF and WB applications and shows reactivity with Human samples. The MA5-17086 immunogen is purified recombinant fragment of human GUCY1A3 (amino acids: 22-214) expressed in E. Coli. MA5-17086 detects GUCY1A3 which has a predicted molecular weight of approximately 77.5kDa.

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

Specifications

• Antigen: GUCY1A3
• Applications: ELISA, Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: 3G6B2
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 0.05% sodium azide
• Gene: GUCY1A1
• Gene Accession No.: Q02108
• Gene Alias: 1200016O07Rik; 4.6.1.2; alpha 1 sGC; GC-SA3; GCSalpha1; GC-S-alpha-1; GCS-alpha1; GCS-alpha-1; GCS-alpha-3; guanylate cyclase 1 soluble subunit alpha; guanylate cyclase 1, soluble, alpha 3; Guanylate cyclase soluble alpha 1 (GTP pyrophosphate - lyase); Guanylate cyclase soluble subunit alpha-1; Guanylate cyclase soluble subunit alpha-3; Guanylate cyclase, soluble, alpha 1 (GTP pyrophosphate - lyase); GUC1A3; GUCA3; GUCSA3; Gucy1a1; GUCY1A3; MYMY6; SGC; sGC-alpha1; soluble guanylate cyclase large subunit
• Gene Symbols: GUCY1A1
• Host Species: Mouse
• Immunogen: Purified recombinant fragment of human GUCY1A3 (amino acids: 22-214) expressed in E. Coli.
• Purification Method: Protein G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2982
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1