Invitrogen™ GUCY1B2 Monoclonal Antibody (GC25)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA123047

Catalog No. PIMA123047

Description

MA1-23047 detects beta subunit of human soluble Guanylate Cyclase.

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one 72 kDa alpha subunit and one 65 kDa beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme.

Specifications

• Antigen: GUCY1B2 (soluble)
• Classification: Monoclonal
• Concentration: 2.7 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: O75343
• Gene Symbols: GUCY1B2
• Immunogen: Recombinant full length protein: human soluble guanylate cyclase alpha1 beta1 heterodimer.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG2a

• Applications: ELISA, Immunohistochemistry, Western Blot
• Clone: GC25
• Conjugate: Unconjugated
• Gene: GUCY1B2
• Gene Alias: B930025B03; GCS beta2; GC-SB2; GCS-beta2; GCS-beta-2; guanylate cyclase 1 soluble subunit beta 2 (pseudogene); guanylate cyclase 1, soluble, beta 2; Guanylate cyclase soluble beta 2 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit beta-2; Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase); Gucy1b2; Gucy1b2a; Gucy1b2b; SGC; soluble guanylate cyclase beta 2a; soluble guanylate cyclase beta 2b; soluble guanylyl cyclase beta2 subunit
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 2974
• Content And Storage: 4°C, do not freeze
• Form: Liquid