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Invitrogen™ GUCY1B2 Monoclonal Antibody (GC25)
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Catalog No. PIMA123047
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200 μg
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Catalog No. Quantity
PIMA123047 200 μg
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Catalog No. PIMA123047 Supplier Invitrogen™ Supplier No. MA123047
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Description

Mouse Monoclonal Antibody

MA1-23047 detects beta subunit of human soluble Guanylate Cyclase.

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide. The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide (NO). It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme containing heterodimer, consisting of one 72 kDa alpha subunit and one 65 kDa beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide, which weakly stimulates the enzyme.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GUCY1B2
Applications ELISA, Immunohistochemistry, Western Blot
Classification Monoclonal
Clone GC25
Concentration 2.7 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene GUCY1B2
Gene Accession No. O75343
Gene Alias B930025B03; GCS beta2; GC-SB2; GCS-beta2; GCS-beta-2; guanylate cyclase 1 soluble subunit beta 2 (pseudogene); guanylate cyclase 1, soluble, beta 2; Guanylate cyclase soluble beta 2 (GTP pyrophosphate - lyase); guanylate cyclase soluble subunit beta-2; Guanylate cyclase, soluble, beta 2 (GTP pyrophosphate - lyase); Gucy1b2; Gucy1b2a; Gucy1b2b; SGC; soluble guanylate cyclase beta 2a; soluble guanylate cyclase beta 2b; soluble guanylyl cyclase beta2 subunit
Gene Symbols GUCY1B2
Host Species Mouse
Immunogen Recombinant hsGC alph 1-beta 1 heterodimer.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2974
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG2a
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