Invitrogen™ GUCY1B3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575169

Catalog No. PIPA575169

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

Specifications

• Antigen: GUCY1B3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: GUCY1B1
• Gene Alias: beta 1 sGC; GCbeta1; GCS beta1; GCS beta3; GC-SB3; GCSbeta1; GC-S-beta-1; GCS-beta1; GCS-beta-1; GCSbeta3; GCS-beta3; GCS-beta-3; guanylate cyclase 1 soluble subunit beta; guanylate cyclase 1 soluble subunit beta 1; guanylate cyclase 1, soluble, beta 3; guanylate cyclase 70 kDa subunit; guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; GUC1B3; GUCB3; GUCSB3; Gucy1b1; Gucy1b3; nitric oxide-sensitive guanylyl cyclase beta 1 subunit; NO-sensitive GC beta 1 subunit; NO-sensitive guanylyl cyclase beta 1 subunit; SGC; sgc1b1; si:ch73-34b5.3; soluble guanylate cyclase 1 beta 3; soluble guanylate cyclase beta-1 subunit; soluble guanylate cyclase small subunit; soluble guanylate cyclase small subunit beta 1; soluble guanylyl cyclase beta1 subunit
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25202, 2983, 54195
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O54865, P20595, Q02153
• Gene Symbols: GUCY1B1
• Immunogen: Synthetic peptide to the N-terminus of Human GUCY1B3.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov