Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Antibodies
  4. Primary Antibodies
  5. All Primary Antibodies
  6. PIPA5104526

Invitrogen™ GUCY1B3 Polyclonal Antibody
GREENER_CHOICE

Catalog No. PIPA5104526
Change view
Click to view available options
Quantity:
100 μL
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
PIPA5104526 100 μL
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
Catalog No. PIPA5104526 Supplier Invitrogen™ Supplier No. PA5104526
Add to Cart
Add to Cart

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total GCYB1.

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GUCY1B3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene GUCY1B1
Gene Accession No. O54865, P20595, Q02153
Gene Alias beta 1 sGC; GCbeta1; GCS beta1; GCS beta3; GC-SB3; GCSbeta1; GC-S-beta-1; GCS-beta1; GCS-beta-1; GCSbeta3; GCS-beta3; GCS-beta-3; guanylate cyclase 1 soluble subunit beta; guanylate cyclase 1 soluble subunit beta 1; guanylate cyclase 1, soluble, beta 3; guanylate cyclase 70 kDa subunit; guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; GUC1B3; GUCB3; GUCSB3; Gucy1b1; Gucy1b3; nitric oxide-sensitive guanylyl cyclase beta 1 subunit; NO-sensitive GC beta 1 subunit; NO-sensitive guanylyl cyclase beta 1 subunit; SGC; sgc1b1; si:ch73-34b5.3; soluble guanylate cyclase 1 beta 3; soluble guanylate cyclase beta-1 subunit; soluble guanylate cyclase small subunit; soluble guanylate cyclase small subunit beta 1; soluble guanylyl cyclase beta1 subunit
Gene Symbols GUCY1B1
Host Species Rabbit
Immunogen A synthesized peptide derived from human GUCY1B3(Accession Q02153), corresponding to amino acid residues M1-L51.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25202, 2983, 54195
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
Show More Show Less

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.