Invitrogen™ GUCY1B3 Recombinant Rabbit Monoclonal Antibody (5O8D9)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA538086

Catalog No. PIMA538086

Description

Positive Samples: U-87MG, Mouse lung, Mouse brain, Mouse heart, Rat brain Immunogen sequence: MYGFVNHALE LLVIRNYGPE VWEDIKKEAQ LDEEGQFLVR IIYDDSKTYD LVAAASKVLN LNAGEILQMF GKMFFVFCQE SGYDTILRVL GSNVREFLQN.

Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase, a soluble form (GCS or sGC), which act as receptors for nitric oxide and a membrane-bound receptor form (GC), which are peptide hormone receptors. The GC-C protein is composed of an extracellular domain, a single transmembrane domain, and a cytoplasmic region consisting of a kinase-like domain and a catalytic domain. It is expressed as two differentially glycosylated forms, a 130 kDa precursor form present in the endoplasmic reticulum and a 145 kDa form present on the plasma membrane. Ligand binding to the extracellular domain of GC-C promotes the accumulation of cGMP. GC-C acts as the receptor for heatstable enterotoxins, small peptides secreted by some pathogenic strains of E. coli that cause severe secretory diarrhea. GC-C also binds to guanylin and uroguanylin peptides, which modulate renal function in response to oral salt load.

Specifications

• Antigen: GUCY1B3
• Classification: Recombinant Monoclonal
• Concentration: 1.5 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O54865, P20595, Q02153
• Gene Symbols: GUCY1B1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Guanylyl Cyclase beta 1 (GUCY1B3) (Q02153).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Clone: 5O8D9
• Conjugate: Unconjugated
• Gene: GUCY1B1
• Gene Alias: beta 1 sGC; GCbeta1; GCS beta1; GCS beta3; GC-SB3; GCSbeta1; GC-S-beta-1; GCS-beta1; GCS-beta-1; GCSbeta3; GCS-beta3; GCS-beta-3; guanylate cyclase 1 soluble subunit beta; guanylate cyclase 1 soluble subunit beta 1; guanylate cyclase 1, soluble, beta 3; guanylate cyclase 70 kDa subunit; guanylate cyclase soluble subunit beta-1; Guanylate cyclase soluble subunit beta-3; guanylate cyclase, soluble, beta 1; GUC1B3; GUCB3; GUCSB3; Gucy1b1; Gucy1b3; nitric oxide-sensitive guanylyl cyclase beta 1 subunit; NO-sensitive GC beta 1 subunit; NO-sensitive guanylyl cyclase beta 1 subunit; SGC; sgc1b1; si:ch73-34b5.3; soluble guanylate cyclase 1 beta 3; soluble guanylate cyclase beta-1 subunit; soluble guanylate cyclase small subunit; soluble guanylate cyclase small subunit beta 1; soluble guanylyl cyclase beta1 subunit
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 25202, 2983, 54195
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov