Invitrogen™ GUK1 Monoclonal Antibody (OTI4A8)

Catalog No.	Quantity
PIMA525501	100 μL

Catalog No. PIMA525501 Supplier Invitrogen™ Supplier No. MA525501

Description

Mouse Monoclonal Antibody

GUK1 Monoclonal Antibody for Western Blot, IHC (P), Flow

Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain, an SH3 domain as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologs) and include Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junction protein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); vertebrate 55 kD erythrocyte membrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However these proteins retain the residues known, in GK, to be involved in the binding of MP.

Specifications

• Antigen: GUK1
• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI4A8
• Concentration: 0.47 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: GUK1
• Gene Accession No.: Q16774
• Gene Alias: AA409738; AL033299; AL033300; ATP:GMP phosphotransferase; ATP:GMP-phosphotransferase; AV026611; Gmk; GMP kinase; GMPK; Guanylate kinase; guanylate kinase 1; GUK; GUK1; Guk-1; RP11-520H14.2
• Gene Symbols: GUK1
• Host Species: Mouse
• Immunogen: Full length human recombinant protein of GUK1 produced in HEK293T cell.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 2987
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1