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Invitrogen™ GUK1 Polyclonal Antibody
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Catalog No. PIPA523119
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100 μL
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PIPA523119 100 μL
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Catalog No. PIPA523119 Supplier Invitrogen™ Supplier No. PA523119
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Description

Rabbit Polyclonal Antibody

This antibody will detect any Caspase-12 cleavage subunit containing amino acids 100-117.

Guanylate kinase (GK) catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes (such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus. Proteins containing one or more copies of the DHR domain, an SH3 domain as well as a C-terminal GK-like domain, are collectively termed MAGUKs (membrane-associated guanylate kinase homologs) and include Drosophila lethal(1)discs large-1 tumor suppressor protein (gene dlg1); mammalian tight junction protein Zo-1; a family of mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); vertebrate 55 kD erythrocyte membrane protein (p55); C. elegans protein lin-2; rat protein CASK; and human proteins DLG2 and DLG3. There is an ATP-binding site (P-loop) in the N-terminal section of GK, which is not conserved in the GK-like domain of the above proteins. However these proteins retain the residues known, in GK, to be involved in the binding of MP.
TRUSTED_SUSTAINABILITY

Specifications

Antigen GUK1
Applications Flow Cytometry, Western Blot
Classification Polyclonal
Concentration Conc. Not Determined
Conjugate Unconjugated
Formulation Whole serum with 50% glycerol and 0.025% sodium azide
Gene GUK1
Gene Accession No. Q16774
Gene Alias AA409738; AL033299; AL033300; ATP:GMP phosphotransferase; ATP:GMP-phosphotransferase; AV026611; Gmk; GMP kinase; GMPK; Guanylate kinase; guanylate kinase 1; GUK; GUK1; Guk-1; RP11-520H14.2
Gene Symbols GUK1
Host Species Rabbit
Immunogen Within the range of amino acids 128-166 of human GUK1 protein.
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 2987
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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