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  5. Tocris Bioscience™ GW 2580

Tocris Bioscience™ GW 2580
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Catalog No. 567350
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Catalog No. Quantity
56-735-0 50 mg
56-731-0 10 mg
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Catalog No. 56-735-0 Supplier Tocris Bioscience™ Supplier No. 5673/50
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Description

Selective cFMS kinase inhibitor; orally bioavailable

GW 2580 is a potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.

Specifications

Chemical Name or Material 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine
CAS 870483-87-7
Quantity 50 mg
Target Additional RTK Inhibitors
Molecular Formula C20H22N4O3
Formula Weight 366.41
Purity >99%
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