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  5. Tocris Bioscience™ GW 280264X

Tocris Bioscience™ GW 280264X
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Catalog No. RD703010
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent ADAM10 and ADAM17 inhibitor

GW 280264X is a potent ADAM (A Disintegrin and Metalloproteinase) 17 and ADAM10 inhibitor (IC50 values of 8 nM and 11.5 nM, respectively). It inhibits constitutive and PMA-inducible CX3CL1 shedding and increases adhesive properties in CX3CL1 transfected cells (IC50 = 1 μM in COS-7 and ECV-304 cells). GW 280264X treatment in mice significantly improves functional recovery after spinal cord injury.

Specifications

Chemical Name or Material Phenylmethyl N-[(5 S)-5-[[(2 R,3 S)-3-(formylhydroxyamino)-2-(2-methylpropyl)-1-oxohexyl]amino]-6-oxo-6-(2-thiazolylamino)hexyl]carbamate
CAS 866924-39-2
Quantity 10 mg
Target Synthetic Metalloprotease Inhibitors
Molecular Formula C28H41N5O6S
Purity 0.98
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