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Tocris Bioscience™ GW 4869

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Quantity:
10 mg
Description
GW 4869 is a selective neutral sphingomyelin phosphodiesterase (N-SMase) inhibitor (IC50 = 1 μM). Exhibits selectivity for neutral sphingomyelinase over acid sphingomyelinase (a-SMase) at concentrations up to 150 μM as well as B. cereus PC-PLC, human lyso-PAF PLC, and bovine PP2A at 10 μM. Blocks exosome biogenesis. Inhibits TNF-α-induced sphingomyelin hydrolysis and TNF-α-induced cell death in MCF-7 cells. Reverses hypoxia-induced pulmonary vasoconstriction in rats. Neuroprotective.
Specifications
Specifications
Chemical Name or Material | 3,3 '-(1,4-Phenylene)bis[N-[4-(4,5-dihydro-1 H-imidazol-2-yl)phenyl]-2-propenamide] ditrifluoroacetate |
Quantity | 10 mg |
Target | Hydrolase Inhibitors |
Molecular Formula | C30H28N6O20.2 CF3COOH |
Purity | 0.9 |
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