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Tocris Bioscience™ GX 201
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Catalog No. 702910 Shop All Novus Biologicals Products
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70-291-0 10 mg
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Catalog No. 70-291-0 Supplier Tocris Bioscience™ Supplier No. 7029/10
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Description

Potent and selective Nav1.7 blocker; analgesic

GX 201 is a potent and selective Nav1.7 blocker (IC50 = 3.2 nM). Exhibits 10x selectivity for Nav1.7 over Nav1.1, Nav1.2, and Nav1.6 channels. Displays prolonged residency time on the Nav1.7 channel. Chronic dosing increases compound potency ∽10-fold and provides efficacy that persists after the compound has cleared from plasma. Suppresses neuropathic pain in a mouse diabetic neuropathy model. Analgesic.

Specifications

Chemical Name or Material 4-[[1-[[2-Chloro-5-(trifluoromethyl)phenyl]methyl]-4-piperidinyl]methoxy]-5-cyclopropyl-2-fluoro-N-(methylsulfonyl)benzamide
CAS 1788071-27-1
Quantity 10 mg
Target Voltage-gated Sodium Channel Blockers
Molecular Formula C25H27ClF4N2O4S
Purity 0.98
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