Invitrogen™ GZMB/GZMH Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115323

Catalog No. PIPA5115323

Description

Antibody detects endogenous levels of total Granzyme B/H.

GZMB/GZMH are members of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016].

Specifications

• Antigen: GZMB/GZMH
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Gzmb
• Gene Alias: AI553453; C11; cathepsin G-like 1; Cathepsin G-like 2; cathepsin G-like 2, protein h-CCPX; CCP1; CCP-1/C11; CCPI; CCP-X; CGL1; CGL-1; CGL2; CGL-2; CSPB; CSP-B; CSP-C; CTLA1; CTLA-1; CTSGL1; CTSGL2; Cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic serine protease C; Cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; cytotoxin serine protease-C; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme H; granzyme H (cathepsin G-like 2, protein h-CCPX); Granzyme-2; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; GZMB; GZMH; GZMH/GZMB; HLP; human lymphocyte protein; Lymphocyte protease; Natural killer cell protease 1; RNKP-1; SECT; T-cell serine protease 1-3E
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 14939, 171528, 2999, 3002
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P04187, P10144, P18291, P20718
• Gene Symbols: Gzmb, GZMH
• Immunogen: A synthesized peptide derived from human GZMB(Accession P10144), corresponding to amino acid residues M1-G50.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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