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Invitrogen™ GZMB/GZMH Polyclonal Antibody
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Catalog No. PIPA5115323
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PIPA5115323 100 μL
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Catalog No. PIPA5115323 Supplier Invitrogen™ Supplier No. PA5115323
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Granzyme B/H.

GZMB/GZMH are members of the granzyme subfamily of proteins, part of the peptidase S1 family of serine proteases. The encoded preproprotein is secreted by natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) and proteolytically processed to generate the active protease, which induces target cell apoptosis. This protein also processes cytokines and degrades extracellular matrix proteins, and these roles are implicated in chronic inflammation and wound healing. Expression of this gene may be elevated in human patients with cardiac fibrosis. [provided by RefSeq, Sep 2016].
TRUSTED_SUSTAINABILITY

Specifications

Antigen GZMB/GZMH
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide
Gene Gzmb
Gene Accession No. P04187, P10144, P18291, P20718
Gene Alias AI553453; C11; cathepsin G-like 1; Cathepsin G-like 2; cathepsin G-like 2, protein h-CCPX; CCP1; CCP-1/C11; CCPI; CCP-X; CGL1; CGL-1; CGL2; CGL-2; CSPB; CSP-B; CSP-C; CTLA1; CTLA-1; CTSGL1; CTSGL2; Cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic serine protease C; Cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; cytotoxin serine protease-C; fragmentin; fragmentin 2; fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); granzyme B(G,H); Granzyme H; granzyme H (cathepsin G-like 2, protein h-CCPX); Granzyme-2; granzyme-like protein 1; granzyme-like protein I; GRB; GZB; GZMB; GZMH; GZMH/GZMB; HLP; human lymphocyte protein; Lymphocyte protease; Natural killer cell protease 1; RNKP-1; SECT; T-cell serine protease 1-3E
Gene Symbols Gzmb, GZMH
Host Species Rabbit
Immunogen A synthesized peptide derived from human GZMB(Accession P10144), corresponding to amino acid residues M1-G50.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 14939, 171528, 2999, 3002
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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