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H-2Ld/H-2Db Mouse anti-Mouse, Brilliant Violet 421, Clone: 28-14-8, BD Optibuild™

Catalog No. BDB742468 Shop All BD Biosciences Products
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Catalog No. BDB742468 Supplier BD Biosciences Supplier No. 742468
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Description

Mouse Monoclonal Antibody

The 266 monoclonal antibody specifically binds to CD105. CD105 presents an integral membrane homodimer protein with subunits of 95 kDa found on vascular endothelial cells and syncytiotrophoblasts of placenta. CD105 is weakly expressed on stromal fibroblasts. It is also expressed on U937 cells, activated macrophages, and mesenchymal stem cells. CD105 is a component of the TGF-βreceptor system in human umbilical vein endothelial cells and binds TGF-β1 and TGF-β3 with high affinity but does not bind toTGF-β2. Expression of CD105 is increased on activated endothelium in tissues undergoing angiogenesis, such as in tumors, or in cases of wound healing or dermal inflammation.

The antibody was conjugated to BD Horizon™ BV421 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 407nm and Em Max at 421nm, BD Horizon BV421 can be excited by the violet laser and detected in the standard Pacific Blue™ filter set (eg, 450/50nm filter). BD Horizon BV421 conjugates are very bright, often exhibiting a 10 fold improvement in brightness compared to Pacific Blue conjugates. BV421 is a polymer-based dye excited by the violet laser and is one of the brightest fluorochromes offered by BD Biosciences. Conjugates are typically 10 times brighter than Pacific Blue™ conjugates and are often as bright as or brighter than PE conjugates. Due to nearly identical excitation and emission properties but different spillover characteristics, BD Horizon BV421, Pacific Blue™, and BD Horizon™ V450 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Specifications

Antigen H-2Ld/H-2Db
Classification Monoclonal
Clone 28-14-8
Concentration 0.2mg/mL
Conjugate Brilliant Violet 421
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias H-2Db/H-2Ld, H2-Db/H2-Ld, Histocompatibility-2 Db/Ld
Host Species Mouse
Immunogen C3H.SW mouse splenocytes
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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