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H1N1 Hemagglutinin 2 Rabbit anti-Human, Polyclonal, Bioss Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  BiossSupplier Diversity Partner BS2003R

Catalog No. 50-198-4400



Description

Description

Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. Influenza A Virus (strain swl A/California/04/2009 H1N1).
Specifications

Specifications

H1N1 Hemagglutinin 2
1 μg/mL
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Rabbit
IgG
100 μL
-20°C
Primary
Human
ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Unconjugated
Liquid
KLH conjugated synthetic peptide derived from Influenza A Virus Hemagglutinin (strain swl A/California/04/2009 H1N1).
Protein A
RUO
Antibody
Polyclonal
SDS
Documents
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