H3-K4-HMTase SETD7 Rabbit anti-Human, Polyclonal, Bioss

Rabbit Polyclonal Antibody

Supplier:  Bioss BS6191R

Catalog No. 50-198-7114

Description

Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.

Specifications

• Antigen: H3-K4-HMTase SETD7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Setd7
• Gene Alias: 1600028F23Rik; FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase; H3-K4-HMTase SETD7; H3K4MT; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Kiaa1717; KMT7; Lysine N-methyltransferase 7; mKIAA1717; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; Set7; SET7/9; Set9; Setd7
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 80854
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 μg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene Accession No.: Q8WTS6
• Gene Symbols: Setd7
• Immunogen: KLH conjugated synthetic peptide derived from human Histone H4 K4 methyltransferase SETD7.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG