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H3-K4-HMTase SETD7 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501987114
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50-198-7114 100 μL
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Catalog No. 50-198-7114 Supplier Bioss Supplier No. BS6191R
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Description

Rabbit Polyclonal Antibody

Histone methyltransferase that specifically monomethylates ′Lys-4′ of histone H3. H3 ′Lys-4′ methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates ′Lys-189′ of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates ′Lys-372′ of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Also able to demethylated ′Lys-372′ of p53/TP53 in vitro.

Specifications

Antigen H3-K4-HMTase SETD7
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene Setd7
Gene Accession No. Q8WTS6
Gene Alias 1600028F23Rik; FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase; H3-K4-HMTase SETD7; H3K4MT; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; Histone-lysine N-methyltransferase SETD7; Kiaa1717; KMT7; Lysine N-methyltransferase 7; mKIAA1717; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; Set7; SET7/9; Set9; Setd7
Gene Symbols Setd7
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human Histone H4 K4 methyltransferase SETD7.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 80854
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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