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Invitrogen™ HACE1 Monoclonal Antibody (8D3), Biotin
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Catalog No. PIMA517702
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100 μg
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Catalog No. Quantity
PIMA517702 100 μg
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Catalog No. PIMA517702 Supplier Invitrogen™ Supplier No. MA517702
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Description

Mouse Monoclonal Antibody

MA5-17702 targets Hace 1 in ELISA, IF, IHC (P), and WB applications and shows reactivity with Human samples. The MA5-17702 immunogen is mouse monoclonal antibodies raised against His-tagged recombinant full length Human HACE1.

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HACE1
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 8D3
Concentration 0.1 mg/mL
Conjugate Biotin
Formulation PBS with 4-5mg/mL BSA and 0.02% sodium azide
Gene HACE1
Gene Accession No. Q8IYU2
Gene Alias 1700042J16Rik; A730034A22Rik; BC025474; E3 ubiquitin-protein ligase HACE1; hace 1; Hace1; HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1; KIAA1320; SPPRS
Gene Symbols HACE1
Host Species Mouse
Immunogen Mouse monoclonal antibodies raised against His-tagged recombinant full length Human HACE1.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 57531
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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