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Invitrogen™ HACE1 Monoclonal Antibody (8D3), FITC
Mouse Monoclonal Antibody
Supplier: Invitrogen™ MA517703
Description
MA5-17703 targets Hace 1 in ELISA, IF, IHC (P), and WB applications and shows reactivity with Human samples. The MA5-17703 immunogen is mouse monoclonal antibodies raised against His-tagged recombinant full length Human HACE1.
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Specifications
HACE1 | |
Monoclonal | |
0.1 mg/mL | |
PBS with 4-5mg/mL BSA and 0.02% sodium azide | |
Q8IYU2 | |
HACE1 | |
Mouse monoclonal antibodies raised against His-tagged recombinant full length Human HACE1. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry | |
8D3 | |
FITC | |
HACE1 | |
1700042J16Rik; A730034A22Rik; BC025474; E3 ubiquitin-protein ligase HACE1; hace 1; Hace1; HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1; KIAA1320; SPPRS | |
Mouse | |
Protein G | |
RUO | |
57531 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. | |
Liquid |
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