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Invitrogen™ HACE1 Polyclonal Antibody
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Catalog No. PIPA5103812
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100 μL
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PIPA5103812 100 μL
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Catalog No. PIPA5103812 Supplier Invitrogen™ Supplier No. PA5103812
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total HACE1.

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
TRUSTED_SUSTAINABILITY

Specifications

Antigen HACE1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene HACE1
Gene Accession No. D3ZBM7, Q3U0D9, Q8IYU2
Gene Alias 1700042J16Rik; A730034A22Rik; BC025474; E3 ubiquitin-protein ligase HACE1; hace 1; Hace1; HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1; KIAA1320; SPPRS
Gene Symbols HACE1
Host Species Rabbit
Immunogen A synthesized peptide derived from human HACE1(Accession Q8IYU2), corresponding to amino acid residues D777-E827.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 209462, 361866, 57531
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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