Invitrogen™ HACE1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5117159

Catalog No. PIPA5117159

Description

Positive Samples: 293T, HeLa, Mouse brain, Mouse lung, Mouse spleen, Mouse testis Immunogen sequence: MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT.

E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.

Specifications

• Antigen: HACE1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: HACE1
• Gene Alias: 1700042J16Rik; A730034A22Rik; BC025474; E3 ubiquitin-protein ligase HACE1; hace 1; Hace1; HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1; KIAA1320; SPPRS
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 209462, 361866, 57531
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.65 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: D3ZBM7, Q3U0D9, Q8IYU2
• Gene Symbols: HACE1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human HACE1 (NP_0658222).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG